Intervention

As the incidence of OAC increases steadily in Western countries in tandem with increasing overweight and obesity, there is a need to examine how risk and outcome may be modified and optimised through more personalised lifestyle interventions. Obesity is not just excess adipose tissue. Certain dietary elements, including saturated fatty acids (SFA) are particularly deleterious. Overfeeding of SFA specifically increases visceral adipose tissue in men, which in turn could augment risk of BO transitioning to OAC. Saturated fats are pro-oncogenic and contribute to the transition from BO to OAC, thereby justifying more rigorous investigation of diet and exercise interventions towards better quality of life. Physical activity behaviours and the impact of a diagnosis and risk of progression on overall quality of life are poorly understood in people with BO. This work package will explore correlates of physical activity as well as mental health and overall quality of life in BO patients. The overall aim of work package 2 is to assess how lifestyle interventions influence inflammation and dysmetabolism in BO and OAC survivorship.