Project Lay Summary

Oesophageal cancer remains to be a major global health challenge which highlights the need for effective prevention strategies and expanding the treatment options. Emerging research indicates that commonly used medications, including antibiotics, aspirin and statins, may influence the risk of developing oesophageal adenocarcinoma (OAC), particularly with prolonged use. However, research gaps remain in understanding what drives progression from premalignant conditions such as Barrett’s oesophagus, to high-grade dysplasia or OAC.

For this PhD, we will investigate these associations using large healthcare datasets, including GP records, prescribing records, and linked cancer registry data. By identifying potential patterns in medication use and OAC risk, this study aims to provide insights that could improve prescribing practices and preventive strategies, especially for high-risk patients.