The 2025 All-Ireland Cancer Network (AllCaN) Oesophageal Symposium took place in Riddel Hall, Queen's University Belfast, Monday 20th October 2025. The symposium brought together clinicians, researchers, PPI (patient & public involvement) representatives, trainees and industry collaborators to review progress across the AllCaN Oesophageal programme and to map clinical and research priorities for the next 12-24 months. Like 2024's symposium, sessions covered the work packages of prevention and intervention (session 1), targeted diagnostics and novel therapeutics (session 2), and concluded with a guest lecture and a high-value open panel discussion session (session 3). The meeting combined formal presentations with rapid roundtable idea boards and an active poster session to promote cross-discipline collaboration. Progress and new data from all of AllCaN Oesophageal’s work packages was presented.